Beneficial Effects of Lactobacillus plantarum Strains on Non-Alcoholic Fatty Liver Disease in High Fat/High Fructose Diet-Fed Rats

Autor: Do Yeun Jeong, Eun Jung Park, Sung Min Kim, Hae-Jeung Lee, Jihee Kang, Gun-Seok Park, You-Suk Lee, Yong Hyun Lee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Antioxidant
medicine.medical_treatment
Disease
Weight Gain
Lactobacillus plantarum
Antioxidants
Feces
0302 clinical medicine
chemistry.chemical_classification
Nutrition and Dietetics
biology
Fatty liver
food and beverages
Alanine Transaminase
Liver
030211 gastroenterology & hepatology
medicine.symptom
Diet
Carbohydrate Loading
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
Normal diet
lcsh:TX341-641
Fructose
Diet
High-Fat
Article
03 medical and health sciences
Internal medicine
high-fat/high-fructose diet
medicine
Animals
Aspartate Aminotransferases
business.industry
Lipogenesis
Probiotics
nutritional and metabolic diseases
non-alcoholic fatty liver disease
medicine.disease
biology.organism_classification
digestive system diseases
Rats
030104 developmental biology
Endocrinology
Enzyme
chemistry
Fermentation
business
Weight gain
Food Science
Zdroj: Nutrients
Volume 12
Issue 2
Nutrients, Vol 12, Iss 2, p 542 (2020)
ISSN: 2072-6643
DOI: 10.3390/nu12020542
Popis: Emerging evidence suggests that probiotics are beneficial in non-alcoholic fatty liver disease (NAFLD). This study aimed to explore the effects of two Lactobacillus plantarum strains, ATG-K2 and ATG-K6 (isolated from Korean fermented cabbage), in a rat model of high fat/high fructose (HF/HF) diet-induced NAFLD. Rats with NAFLD were randomized into four groups (HF/HF diet control, (HC)
HF/HF diet with silymarin, (PC)
HF/HF diet with ATG-K2, (K2)
and HF/HF diet with ATG-K6, (K6)) with healthy rats on a normal diet serving as the negative control. After treatment, histopathological and biochemical analyses of the blood and liver tissue were conducted. In addition, fecal microbiota was analyzed using the MiSeq platform. Compared with HC rats, K2 and K6 rats experienced significantly lower body weight gain, displayed decreased hepatic lipid accumulation, had lower serum levels of aspartate aminotransferase and alanine aminotransferase, and showed increased antioxidant enzyme activities. Moreover, de novo lipogenesis-related genes were downregulated following K2 and K6 administration. The fecal microbiota of K2 and K6 rats contained a higher proportion of Bacteriodetes and a lower proportion of Fimicutes than that of HC rats. Taken together, our results suggest that L. plantarum strains ATG-K2 and ATG-K6 are potential therapeutic agents for NAFLD.
Databáze: OpenAIRE
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