Cumulative Dose of Macrocyclic Gadolinium-Based Contrast Agent Improves Detection of Enhancing Lesions in Patients with Multiple Sclerosis
Autor: | Xavier Montalban, Raquel Mitjana, J.F. Corral, Jaume Sastre-Garriga, Alex Rovira, E. Huerga, Mar Tintoré, Cristina Auger |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Gadolinium media_common.quotation_subject chemistry.chemical_element Contrast Media 030218 nuclear medicine & medical imaging Gadobutrol 03 medical and health sciences 0302 clinical medicine medicine Organometallic Compounds Contrast (vision) Humans Radiology Nuclear Medicine and imaging media_common Clinically isolated syndrome medicine.diagnostic_test Dose-Response Relationship Drug Cumulative dose business.industry Multiple sclerosis Adult Brain Magnetic resonance imaging Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Dose–response relationship chemistry Female Neurology (clinical) Radiology business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | AJNR Am J Neuroradiol |
Popis: | BACKGROUND AND PURPOSE: Gadolinium-enhanced MR imaging is currently the reference standard for detecting active inflammatory lesions in patients with multiple sclerosis. The sensitivity of MR imaging for this purpose may vary according to the physicochemical characteristics of the contrast agent used and the acquisition strategy. The purpose of this study was to compare detection of gadolinium-enhancing lesions or active disease following a single or cumulative dose of a macrocyclic gadolinium-based contrast agent with different image acquisition delays in patients with clinically isolated syndrome or relapsing multiple sclerosis. MATERIALS AND METHODS: All patients received a first dose (0.1 mmol/kg) of gadobutrol and, 20 minutes later, a second dose (0.1 mmol/kg), with a cumulative dose of 0.2 mmol/kg. Two contrast-enhanced T1-weighted sequences were performed at 5 and 15 minutes after the first contrast administration, and 2 additional T1-weighted sequences at 5 and 15 minutes after the second contrast administration with a 3T magnet. RESULTS: One hundred fifteen patients were considered evaluable. A significantly larger number of lesions were detected in scans obtained at 5 and 15 minutes after the second contrast injection compared with scans obtained at 5 and 15 minutes after the first injection (P < .001). The number of patients with active lesions on MR imaging was significantly higher after the second dose administration (52.0%, first dose versus 59.2%, second dose; P < .001). CONCLUSIONS: Cumulative dosing of a macrocyclic gadolinium-based contrast agent increases detection of enhancing lesions and patients with active lesions. These data could be considered in the design of MR imaging protocols aimed at detecting active multiple sclerosis lesions. |
Databáze: | OpenAIRE |
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