High-Density Lipoprotein Cholesterol and Apolipoprotein A1 in Synovial Fluid: Potential Predictors of Disease Severity of Primary Knee Osteoarthritis
| Autor: | Ran Chen, Hanhao Dai, Kaibin Zhang, Jianchao Gui, Yisheng Ji, Abdul Aleem Khan, Yang Zhou, Yiqiu Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Biomedical Engineering Physical Therapy Sports Therapy and Rehabilitation Osteoarthritis Severity of Illness Index 03 medical and health sciences chemistry.chemical_compound Arthroscopy 0302 clinical medicine High-density lipoprotein Disease severity Internal medicine Synovial Fluid medicine Immunology and Allergy Synovial fluid Humans Arthroplasty Replacement Knee Clinical Research papers 030304 developmental biology Aged Apolipoproteins B 030203 arthritis & rheumatology 0303 health sciences biology Apolipoprotein A-I business.industry Cholesterol Cholesterol HDL Lipid metabolism Cholesterol LDL Middle Aged Osteoarthritis Knee medicine.disease Endocrinology chemistry Debridement Case-Control Studies biology.protein Apolipoprotein A1 lipids (amino acids peptides and proteins) Female business Biomarkers |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 |
| Popis: | Objectives The aim of this study was to detect levels of common lipid species in serum and synovial fluid (SF) of primary knee osteoarthritis (OA) patients and investigate their correlations with disease severity. Materials and Methods The study enrolled 184 OA patients receiving arthroscopic debridement or total knee arthroplasty and 180 healthy controls between April 2012 and March 2018. Total triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) levels were analyzed in serum and SF of OA patients, and in serum of healthy individuals. The Noyes rating criteria, Kellgren-Lawrence (KL) grading system, and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores were, respectively, used to assess cartilage damage, radiographic severity, and symptomatic severity of OA. Results No significant differences were found in serum TG and ApoB levels between the 2 groups, while OA patients had higher TC and LDL-C levels and lower HDL-C and ApoA1 levels ( P < 0.05). Pearson correlation analysis revealed SF HDL-C and ApoA1 levels were negatively correlated with cartilage damage scores, KL grades as well as WOMAC scores ( P < 0.05), which were still significant after adjusting for confounding factors ( P < 0.05). Receiver operating characteristic curve analysis revealed SF HDL-C (area under the curve [AUC]: 0.816) and ApoA1 (AUC: 0.793) were also good predictors of advanced-stage OA ( P < 0.001). Conclusion SF HDL-C and ApoA1 levels were negatively correlated with cartilage damage, radiographic severity, and symptomatic severity of primary knee OA, emerging as potential biomarkers for radiographic advanced-stage OA, which may serve as predictors of disease severity. |
| Databáze: | OpenAIRE |
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