Kinins and Kinin Receptors in Cardiovascular and Renal Diseases
| Autor: | Nadine Bouby, Christine Richer-Giudicelli, François Alhenc-Gelas, Jean-Pierre Girolami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
kidney Pharmaceutical Science lcsh:Medicine lcsh:RS1-441 Review heart 030204 cardiovascular system & hematology Pharmacology KININASE II kinins lcsh:Pharmacy and materia medica arteries 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Drug Discovery Medicine kallikrein cardiovascular diseases Receptor Kidney angiotensin-converting enzyme/kininaseII diabetes business.industry urogenital system lcsh:R Kallikrein Kinin medicine.disease ischemic heart disease biological factors kinin receptors 030104 developmental biology medicine.anatomical_structure Molecular Medicine business circulatory and respiratory physiology |
| Zdroj: | Pharmaceuticals Pharmaceuticals, Vol 14, Iss 240, p 240 (2021) |
| ISSN: | 1424-8247 |
| Popis: | This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases. Emphasis is put on pharmacological and genetic studies targeting kallikrein; ACE/kininase II; and the two kinin receptors, B1 (B1R) and B2 (B2R), distinguished through the work of Domenico Regoli and his collaborators. Potential therapeutic interest and limitations of the pharmacological manipulation of B1R or B2R activity in cardiovascular and renal diseases are discussed. This discussion addresses either the activation or inhibition of these receptors, based on recent clinical and experimental studies. |
| Databáze: | OpenAIRE |
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