Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders
| Autor: | Maria A. Oquendo, Jennifer A.Y. Johnston, Siyan Fan, Linda Spencer, Anjali Sankar, Amanda Wallace, Brian Pittman, Fei Wang, Elizabeth Lippard, Hilary P. Blumberg |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Bipolar Disorder Adolescent Prefrontal Cortex Uncinate fasciculus Suicide Attempted Hippocampus behavioral disciplines and activities Article Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders Fractional anisotropy medicine Humans Bipolar disorder Gray Matter Young adult Prefrontal cortex Depressive Disorder Major Suicide attempt business.industry Brain Organ Size medicine.disease Magnetic Resonance Imaging White Matter 030227 psychiatry Psychiatry and Mental health Clinical Psychology Diffusion Magnetic Resonance Imaging Mood disorders Case-Control Studies Anisotropy Major depressive disorder Female business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 245:1089-1097 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2018.11.095 |
| Popis: | Background Findings regarding brain circuitry abnormalities in suicide attempters (SAs) converge across bipolar disorder (BD) and major depressive disorder (MDD), the most common disorders observed in suicides. These abnormalities appear to be present during adolescence/young adulthood when suicide rates increase steeply, and suicide is a leading cause of death in this age group. Identification of brain circuitry common to adolescent/young adult SAs with BD and MDD is important for generating widely effective early prevention strategies. We examined brain circuitry in SAs in adolescents/young adults across these two disorders. Methods Eighty-three participants (ages 14–25 years), 46 with BD (21 SAs) and 37 with MDD (19 SAs), underwent structural and diffusion-weighted magnetic resonance scanning. Whole-brain analyses compared gray matter (GM) volume and white matter (WM) fractional anisotropy (FA) between SAs and non-suicide attempters (NSAs) across and within BD and MDD (p Results Across and within BD and MDD, SAs showed differences compared to NSAs in ventral prefrontal cortex (PFC) GM volume and fronto-limbic (including uncinate fasciculus (UF)) WM FA. Exploratory analyses showed additional within-disorder differences for BD SAs in dorsolateral PFC (dlPFC) and hippocampus GM volume and UF FA, and for MDD SAs dorsomedial and dlPFC GM and dorsal frontal WM. However, there was no significant interaction between suicide attempt status and diagnosis. Limitations Modest sample size. Conclusions Common fronto-limbic gray and white matter alterations in adolescent/young adult SAs are potential targets for suicide prevention strategies across mood disorders. Preliminary findings of disorder-specific regional findings could suggest diagnostic-specific optimal targets may exist. |
| Databáze: | OpenAIRE |
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