Additive effects of glucagon and vasopressin on renal Mg reabsorption and urine concentrating ability in the rat
| Autor: | Jean-Marc Elalouf, Christian de Rouffignac, Daoudi Chabane Sari |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Physiology Clinical Biochemistry Parathyroid hormone Glucagon Absorption Kidney Concentrating Ability Excretion Physiology (medical) Internal medicine medicine Animals Magnesium Receptor urogenital system Reabsorption Chemistry Rats Brattleboro Rats Arginine Vasopressin Kidney Tubules Endocrinology Calcitonin Loop of Henle Diabetes Insipidus hormones hormone substitutes and hormone antagonists Glomerular Filtration Rate Hormone |
| Zdroj: | Pflügers Archiv. 407:S66-S71 |
| ISSN: | 1432-2013 0031-6768 |
| DOI: | 10.1007/bf00584932 |
| Popis: | Previous studies demonstrated that in rat kidney, arginine-vasopressin (AVP), glucagon (GLU), calcitonin and parathyroid hormone exert similar effects on the thick ascending limb of Henle's loop (TALH). To ascertain the physiological significance of such multiple hormonal control of TALH function, it is necessary to establish whether one hormone can exert its effect on TALH, even when other hormones are present. We therefore compared renal responses to submaximal (1 ng/min) and maximal (10 ng/min) doses of glucagon in rats deprived of endogenous AVP, GLU, calcitonin and parathyroid hormone with the responses of similar rats given a maximal dose of AVP (40 pg/min). Administration of glucagon or AVP alone reduced Mg fractional excretion, but the reduction was more marked when both hormones were given together. Consequently, their effects were additive, at submaximal and maximal doses. In the presence of AVP + glucagon, urinary osmolality was also higher than in the presence of AVP alone (Umax: 1242 +/- 49 vs. 936 +/- 50 mosmol/kg; p less than 0.001). This latter effect may indicate that AVP and glucagon also exert additive effects on Na reabsorption in the TALH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink