The effects of lacosamide on cognition, quality-of-life measures, and quality of life in patients with refractory partial epilepsy
| Autor: | Evan J. Fertig, Sloka S. Iyengar, Kenneth Perrine, Munazza Malik, Marcelo Lancman, Robert Trobliger, Lorna Myers |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Drug Resistant Epilepsy Lacosamide Clinical Neurology Neuropsychological Tests Profile of mood states Mood/quality of life 03 medical and health sciences Epilepsy Behavioral Neuroscience 0302 clinical medicine Cognition Quality of life Seizures Acetamides Memory span Medicine Humans Prospective Studies Psychiatric Status Rating Scales Refractory business.industry Depression Controlled Oral Word Association Test medicine.disease Partial-onset epilepsy Affect 030104 developmental biology Mood Treatment Outcome Neurology Anesthesia Quality of Life Anticonvulsants Drug Therapy Combination Female Neurology (clinical) Epilepsies Partial business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Epilepsy & Behavior. :27-33 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2016.04.049 |
| Popis: | ObjectiveThe objective of this study was to examine cognitive and quality-of-life measures/quality of life outcomes with adjunctive lacosamide therapy in patients with treatment-resistant partial epilepsy.MethodsThis was a prospective, open-label, nonblinded, adjunctive therapy test–retest (within subjects) study of patients with treatment-resistant partial epilepsy in which outcome (cognitive functioning and mood/quality of life) was measured in the same subject before and after adjunctive lacosamide administration for 24weeks. The cognitive assessment included the following: Controlled Oral Word Association Test, Buschke Selective Reminding Test, Brief Visuospatial Memory Test—Revised, Stroop Color Word Test, Symbol Digit Modalities Test, Digit Span, Digit Cancellation, and Trails A and B. The quality-of-life measures/quality-of-life assessment included the following: Beck Depression Inventory—II, Profile of Mood States, and Quality of Life Inventory—89. Lacosamide was started at 100mg (50mg twice daily) and could be titrated as needed up to 400mg/day (200mg twice daily). Baseline concomitant AEDs were kept constant. Composite scores were calculated for a pre–post difference score for the cognitive and mood/quality-of-life measures separately and used in regression analyses to correct for the effects of age, education, seizure frequency, seizure severity, dose of lacosamide, and number of AEDs at baseline.ResultsThirty-four patients were enrolled (13 males, 21 females). Mean age was 38.8±2.43years. Mean seizure frequency decreased significantly from 2.0±2.55 seizures per week at baseline to 1.02±1.72 seizures per week at posttreatment (t=4.59, p |
| Databáze: | OpenAIRE |
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