Comment on 'World's First Clinical Case of Gene-Activated Bone Substitute Application'
Autor: | I.I. Eremin, Roman V. Deev, A. Y. Drobyshev, Isaev Artur Aleksandrovich, I.Y. Bozo |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Bone substitute Scar tissue Nonunion MEDLINE Case Report 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Text mining Plasmid dna medicine Letter to the Editor General Dentistry business.industry Mandible RK1-715 030206 dentistry medicine.disease Resorption Surgery Vascular endothelial growth factor 030104 developmental biology chemistry Dentistry Clinical case business |
Zdroj: | Case Reports in Dentistry Case Reports in Dentistry, Vol 2016 (2016) Europe PubMed Central Case Reports in Dentistry, Vol 2017 (2017) |
ISSN: | 2090-6447 |
Popis: | Treatment of patients with large bone defects is a complex clinical problem. We have initiated the first clinical study of a gene-activated bone substitute composed of the collagen-hydroxyapatite scaffold and plasmid DNA encoding vascular endothelial growth factor. The first patient with two nonunions of previously reconstructed mandible was enrolled into the study. Scar tissues were excised; bone defects (5–14 mm) between the mandibular fragments and nonvascularized rib-bone autograft were filled in with the gene-activated bone substitute. No adverse events were observed during 12 months of follow-up. In 3 months, the average density of newly formed tissues within the implantation zone was 402.21 ± 84.40 and 447.68 ± 106.75 HU in the frontal and distal regions, respectively, which correlated with the density of spongy bone. Complete distal bone defect repair with vestibular and lingual cortical plates formation was observed in 6 and 12 months after surgery; thereby the posterior nonunion was successfully eliminated. However, there was partial resorption of the proximal edge of the autograft entailed to relapse of the anterior nonunion. Thus, the first clinical data on the safety and efficacy of the gene-activated bone substitute were obtained. Given a high complexity of the clinical situation the treatment, results might be considered as promising. NCT02293031. |
Databáze: | OpenAIRE |
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