Biomarkers for small cell lung cancer: neuroendocrine, epithelial and circulating tumour cells
| Autor: | Anne White, Jian-Mei Hou, Fiona H Blackhall, Rachel Stovold, Suzanne Meredith, Caroline Dive |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Cancer Research medicine.medical_specialty Epithelial-Mesenchymal Transition Lung Neoplasms Pro-Opiomelanocortin medicine.medical_treatment Metastasis Mice Neuroendocrine Cells Internal medicine medicine Biomarkers Tumor Animals Humans Epithelial–mesenchymal transition Neoplasm Metastasis Chemotherapy business.industry Mesenchymal stem cell Clinical course Epithelial Cells medicine.disease Neoplastic Cells Circulating Phenotype Preclinical data Small Cell Lung Carcinoma Peptide Fragments Recombinant Proteins Disease Models Animal Non small cell business |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 76(3) |
| ISSN: | 1872-8332 |
| Popis: | Small cell lung cancer (SCLC) is characterised by an aggressive clinical course with invariable resistance to chemotherapy despite initially high response rates. There has been little improvement in outcome over the past few decades, with no breakthrough yet in targeted therapies. Recent preclinical data and studies of circulating tumour cells (CTCs) highlight distinct cellular heterogeneity within SCLC. Better understanding of how these phenotypes contribute to metastasis and tumour progression might pave the way for development of more successful targeted therapies. Here we review these studies, their implications for future research and for the incorporation of biomarkers reflecting neuroendocrine, epithelial and mesenchymal phenotypes in clinical studies. |
| Databáze: | OpenAIRE |
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