Assessment of DNA damage in relation to heavy metal induced oxidative stress in females with recurrent pregnancy loss (RPL)
| Autor: | Fouza K. Alenazi, Waad Alamro, Samyah Alanazi, Lulwah B. Alahmed, Naif Alenzi, Nourah Al-Mutlaq, Mubark M. Al Abudahash, Nouf Almuhareb, May Alrashed, Hajera Tabassum |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Antioxidant DNA damage QH301-705.5 medicine.medical_treatment medicine.disease_cause 01 natural sciences Miscarriage Andrology 03 medical and health sciences Total antioxidant status medicine ICP-MS Biology (General) Pregnancy business.industry Case-control study Heavy metals medicine.disease Recurrent pregnancy loss 030104 developmental biology Etiology Original Article General Agricultural and Biological Sciences business Oxidative stress 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 28, Iss 9, Pp 5403-5407 (2021) |
| ISSN: | 2213-7106 1319-562X |
| Popis: | Pregnancy termination consecutively for three or more times during the first trimester is termed as Recurrent pregnancy loss (RPL). In addition to the abnormal karyotype, heavy metal induced oxidative damage may contribute as prominent etiological factor in pregnancy termination. Oxidative stress is considered crucial in etiology underlying RPL with altered antioxidant status and subsequent DNA damage. The current case controlled study investigated Total antioxidant capacity (TAC), DNA damage (8OHdG) and heavy metals in RPL group (n = 30) and the women with successful pregnancies and no cases of miscarriage as control group (30 women). Heavy metals -Antimony (Sb) and Arsenic (As) were measured by Inductively Coupled Plasma Mass spectrophotometry (ICP-MS). There was significant decrease in levels of TAC in RPL group compared to healthy pregnant women (P |
| Databáze: | OpenAIRE |
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