Particulate matter and Alzheimer’s disease: an intimate connection

Autor: Devin R. O’Piela, George R. Durisek, Yael-Natalie H. Escobar, Amy R. Mackos, Loren E. Wold
Rok vydání: 2022
Předmět:
Zdroj: Trends in Molecular Medicine. 28:770-780
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2022.06.004
Popis: The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. Particulate matter (PM) includes various gases, liquids, and particles in suspension and is produced by industrial activities such as fossil fuel combustion and natural events including wildfires and volcanic eruptions. Although agencies have attempted to reduce acceptable airborne particulate levels, with urbanization and population growth, these policies have been only moderately effective in mitigating disease progression. A growing area of research is focused on the role of PM exposure in the progression of Alzheimer's disease (AD). This review will summarize the knowns and unknowns of this expanding field.
Databáze: OpenAIRE