Ruthenium-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones
| Autor: | Parthasarathi Das, K. Anil Kumar, Prakash Kannaboina |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Molecular Structure
Pyridones 010405 organic chemistry Organic Chemistry chemistry.chemical_element Isoquinolines 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Ruthenium 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Rapid access Site selective Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organic & Biomolecular Chemistry. 15:5457-5461 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c7ob01277b |
| Popis: | An efficient Ru(ii)-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones in excellent yields. These designed arylated 2-pyridones and 1-isoquinolinones can serve as key structural motifs for accessing functionalized pyridines and isoquinolines. |
| Databáze: | OpenAIRE |
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