Age-Specific Prevalence of Anal and Cervical Human Papillomavirus Infection and High-Grade Lesions in 11 177 Women by Human Immunodeficiency Virus Status: A Collaborative Pooled Analysis of 26 Studies
| Autor: | Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T Goodman, Nancy A Hessol, Beatriz Grinsztejn, Ana P Ortiz, Fanghui Zhao, Erna M Kojic, Rupert Kaul, Isabelle Heard, Imran O Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M Palefsky, Luana L S Rodrigues, Racheal S Dube Mandishora, Reshmie A Ramautarsing, Silvia Franceschi, Sheela V Godbole, Fernanda K Tso, Lynette J Menezes, Chunqing Lin, Gary M Clifford |
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| Rok vydání: | 2023 |
| Předmět: |
Adult
HPV Adolescent Squamous Intraepithelial Lesions Anal Canal Uterine Cervical Neoplasms HIV Infections Cervix Uteri Cervical Cancer Medical and Health Sciences Microbiology Young Adult cervix Prevalence Immunology and Allergy Humans 2.2 Factors relating to the physical environment Aetiology Papillomaviridae Early Detection of Cancer Cancer Human papillomavirus 16 Prevention Papillomavirus Infections Age Factors virus diseases HIV Human Papillomavirus Viruses anus Biological Sciences Anus Neoplasms female genital diseases and pregnancy complications Infectious Diseases Good Health and Well Being Sexually Transmitted Infections HIV/AIDS Female women Infection |
| Zdroj: | The Journal of infectious diseases, vol 227, iss 4 |
| Popis: | Background Age-specific data on anal, and corresponding cervical, human papillomavirus (HPV) infection are needed to inform female anal cancer prevention. Methods We centrally reanalyzed individual-level data from 26 studies reporting HPV prevalence in paired anal and cervical samples by human immunodeficiency virus (HIV) status and age. For women with HIV (WWH) with anal high-grade squamous intraepithelial lesions or worse (HSIL+), we also investigated concurrent cervical cytopathology. Results In HIV-negative women, HPV16 prevalence decreased significantly with age, both at anus (4.3% at 15–24 years to 1.0% at ≥55 years; ptrend = 0.0026) and cervix (7.4% to 1.7%; ptrend < 0.0001). In WWH, HPV16 prevalence decreased with age at cervix (18.3% to 7.2%; ptrend = 0.0035) but not anus (11.5% to 13.9%; ptrend = 0.5412). Given anal HPV16 positivity, concurrent cervical HPV16 positivity also decreased with age, both in HIV-negative women (ptrend = 0.0005) and WWH (ptrend = 0.0166). Among 48 WWH with HPV16-positive anal HSIL+, 27 (56%) were cervical high-risk HPV-positive, including 8 with cervical HPV16, and 5 were cervical HSIL+. Conclusions Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections in the anus persist longer, or occur later in life, than in the cervix, particularly in WWH. This is an important consideration when assessing the utility of cervical screening results to stratify anal cancer risk. |
| Databáze: | OpenAIRE |
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