Daidzein Pro-cognitive Effects Coincided with Changes of Brain Neurotensin1 Receptor and Interleukin-10 Expression Levels in Obese Hamsters
| Autor: | Raffaella Alò, Rosa Maria Facciolo, Marcello Canonaco, Gilda Fazzari, Merylin Zizza, Giovanni Cuda, Tullio Barni, Rosalinda Bruno, Ennio Avolio, Anna Di Vito |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Elevated plus maze Gene Expression Phytoestrogens Hippocampal formation Toxicology Diet High-Fat Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Cricetinae Medicine Animals Receptors Neurotensin Obesity Receptor Nootropic Agents Mesocricetus business.industry General Neuroscience Metabolic disorder Neurodegeneration Daidzein Brain medicine.disease Isoflavones Interleukin-10 Interleukin 10 030104 developmental biology Endocrinology chemistry Exploratory Behavior business 030217 neurology & neurosurgery |
| Zdroj: | Neurotoxicity researchReference. 39(3) |
| ISSN: | 1476-3524 |
| Popis: | At present, concerns are pointing to “tasteful” high-fat diets as a cause of conditioning physical-social states that through alterations of some key emotional- and nutritional-related limbic circuits such as hypothalamic and amygdalar areas lead to obesity states. Feeding and energetic homeostatic molecular mechanisms are part of a complex neuronal circuit accounting for this metabolic disorder. In an attempt to exclude conventional drugs for treating obesity, daidzein, a natural glycosidic isoflavone, which mimics estrogenic neuroprotective properties against increased body weight, is beginning to be preferred. In this study, evident anxiolytic-like behaviors were detected following treatment of high-fat diet hamsters with daidzein as shown by extremely evident (p |
| Databáze: | OpenAIRE |
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