Relationships between glycaemic abnormalities, obesity and insulin resistance in nondiabetic Polynesians of New Caledonia

Autor: R. Defay, Annick Fontbonne, Annie Lacroux, Isabelle Jaussent
Přispěvatelé: Épidémiologie et prévention : environnement et efficacité des interventions (EPIPREV), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM, Ministère de la Coopération, Commission médicale de la province de Nouvelle Calédonie, Rotary Club de Noumea, Lyons Club de Nouméa, Laboratoire Behring
Rok vydání: 2006
Předmět:
Blood Glucose
Male
insulin secretion
Endocrinology
Diabetes and Metabolism
common
medicine.medical_treatment
Medicine (miscellaneous)
Type 2 diabetes
Body Mass Index
0302 clinical medicine
Waist–hip ratio
insulin resistance
Insulin
030212 general & internal medicine
2. Zero hunger
Nutrition and Dietetics
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Middle Aged
Europe
Population Surveillance
common.group
epidemiology
Female
type 2 diabetes
Disease Susceptibility
Polynesians
medicine.medical_specialty
030209 endocrinology & metabolism
Polynesia
Article
03 medical and health sciences
Insulin resistance
New Caledonia
Internal medicine
medicine
Humans
Obesity
Pancreatic hormone
Waist-Hip Ratio
business.industry
medicine.disease
Cross-Sectional Studies
Endocrinology
Melanesia
Insulin Resistance
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Body mass index
Zdroj: Int J Obes (Lond)
Int J Obes (Lond), 2007, 31 (1), pp.109-113. ⟨10.1038/sj.ijo.0803384⟩
ISSN: 1476-5497
0307-0565
DOI: 10.1038/sj.ijo.0803384
Popis: Objective:Polynesians in New Caledonia have an increased risk for developing diabetes, compared to Melanesians or Europeans. They are also more prone to obesity. The aim of this study was to analyse differences in the pre-diabetic state that may explain the varying susceptibility to diabetes between these three ethnic groups, focusing on the balance between insulin resistance and capacity of pancreatic cells to secrete insulin.Design and subjects:The CALDIA Study is a population-based cross-sectional survey of diabetes prevalence conducted in New Caledonia. All participants who did not have diabetes, according to the results of a 0-2 h oral glucose tolerance test (n=392), were selected for analysis.Results:Compared to Europeans, Polynesians and Melanesians had significantly higher body mass indices (BMI) and waist-to-hip ratios (WHRs). Polynesians had higher fasting plasma glucose values than Europeans or Melanesians (6.03 mmol/l, vs 5.78 and 5.46, respectively; P
Databáze: OpenAIRE
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