Design of the Glucose Rate Increase Detector
| Autor: | Dale E. Seborg, Francis J. Doyle, Eyal Dassau, Howard Zisser, Rebecca A. Harvey |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
safety
Meal meal detection Nutrition and Dietetics artificial pancreas Endocrinology Diabetes and Metabolism digestive oral and skin physiology Detector Biomedical Engineering Bioengineering Monitoring system Original Articles User input Artificial pancreas Health Monitoring System Bolus (medicine) Animal science Clinical Research Median time Internal Medicine Simulation Postprandial Hypoglycemia Mathematics |
| Zdroj: | Journal of diabetes science and technology, vol 8, iss 2 |
| ISSN: | 1932-2968 |
| DOI: | 10.1177/1932296814523881 |
| Popis: | Background: The Glucose Rate Increase Detector (GRID), a module of the Health Monitoring System (HMS), has been designed to operate in parallel to the glucose controller to detect meal events and safely trigger a meal bolus. Methods: The GRID algorithm was tuned on clinical data with 40-70 g CHO meals and tested on simulation data with 50-100 g CHO meals. Active closed- and open-loop protocols were executed in silico with various treatments, including automatic boluses based on a 75 g CHO meal and boluses based on simulated user input of meal size. An optional function was used to reduce the recommended bolus using recent insulin and glucose history. Results: For closed-loop control of a 3-meal scenario (50, 75, and 100 g CHO), the GRID improved median time in the 80-180 mg/dL range by 17% and in the >180 range by 14% over unannounced meals, using an automatic bolus for a 75 g CHO meal at detection. Under open-loop control of a 75 g CHO meal, the GRID shifted the median glucose peak down by 73 mg/dL and earlier by 120 min and reduced the time >180 mg/dL by 57% over a missed-meal bolus scenario, using a full meal bolus at detection. Conclusions: The GRID improved closed-loop control in the presence of large meals, without increasing late postprandial hypoglycemia. Users of basal-bolus therapy could also benefit from GRID as a safety alert for missed meal corrections. |
| Databáze: | OpenAIRE |
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