Trypanosoma evansi induces detrimental immuno-catabolic alterations and condition like type-2 diabetes in buffaloes
| Autor: | Vivek K. Singh, Udayraj P. Nakade, Shanker K. Singh, Priyambada Kumari, Satish K. Garg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Trypanosoma medicine.medical_specialty Buffaloes Globulin animal diseases Type 2 diabetes Fatty Acids Nonesterified Antioxidants Protein Carbonylation 03 medical and health sciences chemistry.chemical_compound NEFA Trypanosomiasis Malondialdehyde Diabetes mellitus Internal medicine parasitic diseases medicine Animals 3-Hydroxybutyric Acid biology Catabolism Albumin food and beverages Hemoglobin A Trypanosoma evansi medicine.disease biology.organism_classification Interleukin-10 030104 developmental biology Infectious Diseases Endocrinology Diabetes Mellitus Type 2 chemistry Hyperglycemia Immunology biology.protein Parasitology Blood Chemical Analysis geographic locations |
| Zdroj: | Parasitology International. 67:140-143 |
| ISSN: | 1383-5769 |
| DOI: | 10.1016/j.parint.2017.10.015 |
| Popis: | The present study aimed to investigate the perturbations in immuno-metabolic and redox status of buffaloes with trypanosomosis. Thirteen buffaloes suffering from clinical trypanosomosis and eight apparently healthy buffaloes were included in the present study. Buffaloes with trypanosomosis found to have markedly elevated levels of interleukin-10 (IL-10), nonesterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) in comparison with healthy controls. Whereas, total antioxidant capacity (TAC) and haemoglobin levels of buffaloes with trypanosomosis were significantly lower than the healthy controls. Remarkable elevation in malondialdehyde (MDA) and protein carbonyls (PC) levels were also observed in the diseased buffaloes. Moreover, buffaloes with trypanosomosis were found to have markedly elevated levels of serum glucose, total proteins, globulins, urea and aspartate aminotransferase (AST) and markedly lowered levels of serum calcium, total cholesterol levels and albumin/globulin (A/G) ratio as compared to the controls. Findings of our study evidently suggest that Trypanosoma evansi induces remarkable immunosuppressive and pro-oxidative status with an increased catabolic activity and hyperglycemic condition like type-2 diabetes in naturally infected buffaloes. Therefore, immuno-metabolic and pro-oxidative predicaments should be addressed by the veterinary clinician while managing the clinical cases of trypanosomosis in buffaloes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect