Two years follow up of domain specific cognitive training in relapsing remitting multiple sclerosis: A randomized clinical trial
| Autor: | Raffaella Clerici, Daria Baldini, Laura Compagnucci, Antonio Uccelli, Chiara Calanca, Annalisa Lattuada, Matteo Pardini, Marianna Pattini, Beatrice Allegri, Fabio Bellomi, Leandro Provinciali, Barbara Corso, Cristina Montomoli, Paolo Gallo, Debora Trafficante, Giuseppe Santuccio, Maria Rosaria Tola, Marco Roscio, Ruggero Capra, Giuditta Fregonese, Alice Riccardi, Flavia Mattioli, Angelo Ghezzi, Chiara Stampatori |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Psychological intervention law.invention lcsh:RC321-571 Multiple sclerosis 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Randomized controlled trial law Neuropsychology Internal medicine medicine 030212 general & internal medicine Cognitive rehabilitation therapy Effects of sleep deprivation on cognitive performance lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Cognitive rehabilitation Randomize clinical trial Neuropsychology and Physiological Psychology Original Research Cognition Follow up medicine.disease Cognitive training Physical therapy Psychology 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Behavioral Neuroscience Frontiers in Behavioral Neuroscience, Vol 10 (2016) |
| Popis: | Cognitive rehabilitation in Multiple Sclerosis has been reported to induce neuropsychological improvements, but the persistence of these effects has been scarcely investigated over long follow ups. Here, the results of a multicenter randomized clinical trial are reported, in which the efficacy of 15 week domain specific cognitive training was evaluated at two years follow up in 41 patients. Included patients were randomly assigned either to domain specific cognitive rehabilitation, or to aspecific psychological intervention. Patients who still resulted to be cognitively impaired at one year follow up were resubmitted to the same treatment, whereas the recovered ones were not. Neuropsychological tests and functional scales were administered at two years follow up to all the patients. Results revealed that both at one and at two years follow up more patients in the aspecific group (18/19, 94% and 13/17, 76% respectively) than in the specific group (11/22, 50% and 5/15, 33% respectively) resulted to be cognitively impaired. Furthermore patients belonging to the specific group showed significantly less impaired tests compared with the aspecific group ones (p=.02) and a significant amelioration in the majority of the tests. On the contrary patients in the aspecific group did not change. The specific group subjects also perceived a subjective improvement in their cognitive performance, while the aspecific group patients did not. These results showed that short time domain specific cognitive rehabilitation is a useful treatment for patients with Multiple Sclerosis, shows very longlasting effects, compared to aspecific psychological interventions. Also subjective cognitive amelioration was found in patients submitted to domain specific treatment after two years. |
| Databáze: | OpenAIRE |
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