Toxoplasma infection and risk of epilepsy: A case-control study of incident patients
| Autor: | Mustafa Almukhtar, Ali Alizadeh Khatir, Hossein Ghorbani, Saeed Mehravar, Ali Rostami, Arefeh Babazadeh, Solmaz Alizadeh Moghaddam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Antibodies Protozoan Logistic regression Microbiology Young Adult Epilepsy Risk Factors Seroepidemiologic Studies Internal medicine parasitic diseases medicine Humans Univariate analysis biology business.industry Confounding Case-control study Toxoplasma gondii Odds ratio Middle Aged biology.organism_classification medicine.disease Infectious Diseases Case-Control Studies Immunoglobulin G Etiology business Toxoplasma Toxoplasmosis |
| Zdroj: | Microbial Pathogenesis. 161:105302 |
| ISSN: | 0882-4010 |
| DOI: | 10.1016/j.micpath.2021.105302 |
| Popis: | We performed an age matched case-control study of incident epileptic patients to assess the relationship between Toxoplasma gondii seropositivity and epilepsy. Cases were 94 newly diagnosed patients (mean age, 36.7 ± 15.9) with unprovoked convulsive epilepsy of unknown etiology and controls were 88 healthy individuals (mean age, 37.5 ± 17.1) with no history of epilepsy or neurological disorders. Sera of all subjects were examined for anti-Toxoplasma IgG antibodies using commercially enzyme-linked immunoassays. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using univariate analysis and logistic regression, adjusted for potential confounders. The prevalence of anti-Toxoplasma IgG antibodies in epileptic patients (68.1%; 95%CI, 57.6-77.3%) was significantly higher than healthy controls (47.7%; 95%CI, 36.9-58.6%), indicating a significant relationship between Toxoplasma infection seropositivity and epilepsy (adjusted OR, 2.58; 95%CI, 1.16-5.72; P value |
| Databáze: | OpenAIRE |
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