Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease
| Autor: | Dorothea Collins, Matthew M. Burg, Aaron Soufer, Hooman Ranjbaran, Antonio B. Fernandez, Robert Soufer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Health Status media_common.quotation_subject Coronary Disease Anger Risk Assessment Article Developmental psychology Thinking Coronary artery disease Electrocardiography Norepinephrine Ventricular Dysfunction Left Risk Factors Internal medicine Diabetes mellitus medicine Humans Applied Psychology Aged media_common Endothelin-1 Data Collection Odds ratio Middle Aged medicine.disease Confidence interval Psychiatry and Mental health Rate pressure product Mental Recall Rumination Cardiology Female medicine.symptom Psychology Stress Psychological |
| Zdroj: | Psychosomatic Medicine. 72:348-353 |
| ISSN: | 0033-3174 |
| Popis: | Objective: To determine whether a tendency to angry rumination predicts anger recall (AR) stress-provoked increase in endothelin (ET)-1 among patients with coronary heart disease (CHD). Methods: Patients with chronic stable CHD (n = 105) completed a five-item measure of tendency to angry rumination (DAB-VR) and underwent a laboratory AR stress protocol (15-minute resting baseline [BL], 8-minute AR). Blood samples drawn at end of BL and AR were assayed for ET-1. Change in ET-1 from BL to AR (increase versus decrease/no change) was treated dichotomously in multivariate logistic regression models, including DAB-VR score and potential confounders, to evaluate the contribution of DAB-VR to the prediction of change in ET-1. Results: In the multivariate model, DAB-VR score significantly predicted ET-1 increase (odds ratio, 1.34; 95% confidence interval, 1.10–1.1.63; p = .004), controlling for age, history of diabetes, hypercholesterolemia, rate pressure product, use of β blockers, and statins. Conclusions: A tendency to angry rumination independently predicted AR stress-provoked ET-1 increase among patients with CHD. Given the involvement of ET-1 in plaque rupture, anger rumination tendency may identify vulnerability to anger-triggered acute coronary syndrome through prolongation of initial anger mobilization. The contribution of ruminative thinking to sustained poststress ET-1 elevation and the synergistic relationship of ET-1 during emotional stress with norepinephrine and nitric oxide remain to be explored. |
| Databáze: | OpenAIRE |
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