Structure-activity relationship of some analogues of gastrin and cholecystokinin on intestinal smooth muscle of the guinea-pig

Autor:	P. Mantovani, Éva Vizi, G. Bertaccini, Marianina Impicciatore, J. Zséli, Jozsef Knoll
Rok vydání:	1974
Předmět:	medicine.medical_specialty Contraction (grammar) Guinea Pigs Myenteric Plexus Ileum Stimulation Hexamethonium Compounds Tetrodotoxin In Vitro Techniques digestive system Guinea pig Structure-Activity Relationship Smooth muscle Internal medicine Gastrins medicine Structure–activity relationship Animals Amino Acid Sequence Gastrin Cholecystokinin Pharmacology Dose-Response Relationship Drug Chemistry digestive oral and skin physiology Muscle Smooth General Medicine Acetylcholine Chemoreceptor Cells Electric Stimulation Stimulation Chemical medicine.anatomical_structure Endocrinology Desensitization Immunologic Pentagastrin Gastrointestinal Motility Peptides Ceruletide Muscle Contraction
Zdroj:	Naunyn-Schmiedeberg's archives of pharmacology. 284(3)
ISSN:	0028-1298
Popis:	The structure-activity relationship of gastrin- and cholecystokinin like polypeptides has been studied on intestinal smooth muscle of the guinea pig. The polypeptides studied here elicited reciprocal responses of the two muscle layers of ileum similar to the responses to electrical stimulation. The contraction of the longitudinal muscle and the relaxation of the circular muscle layer in response to peptides was followed by a contraction of circular muscle and a relaxation of longitudinal muscle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f877635e2195e5cf545d921f80c88582 https://pubmed.ncbi.nlm.nih.gov/4279352 Zobrazit plný text záznamu Full text from SpringerLink