Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring
| Autor: | Liangmiao Chen, Hong Yang, Mengmeng Peng, Chen Qs, Zhang Q, Jin Gx, Enling Ye, Zhenzhen Lin, Lechu Yu, Lingqiao Cai, Xuemian Lu, Chi Zhang, Si Gx |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China endocrine system medicine.medical_specialty endocrine system diseases Offspring Statistics as Topic Neuropsychological Tests Nervous System Hypothyroidism Pregnancy medicine Humans Euthyroid Longitudinal Studies Prospective Studies Neonatology Prospective cohort study Subclinical infection Intelligence Tests business.industry Obstetrics Infant Newborn Infant Obstetrics and Gynecology Gestational age medicine.disease Pregnancy Complications Pregnancy Trimester First Thyroxine Prenatal Exposure Delayed Effects Behavior Rating Scale Pediatrics Perinatology and Child Health Gestation Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Perinatology. 35:678-682 |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | To evaluate the effects of gestational subclinical hypothyroidism (SCH) on early neurodevelopment of offspring. A prospective study included 106 infants born to mothers with gestational SCH and 106 infants born to mothers who were euthyroid during pregnancy. The neurodevelopment of 12 to 24-month-old infants was assessed and compared using the Gesell developmental test (revised version). Infants born to mothers with gestational SCH and those born to euthyroid mothers had similar scores on the Gesell development test. No correlations were observed between maternal TSH concentration and Gesell developmental test scores of offspring. Infants born to mothers who had gestational SCH during the first trimester specifically and those born to euthyroid mothers had similar scores on the Gesell development test. No significant correlations were detected between maternal TSH concentration during the first trimester and offspring neurodevelopment. No detectable neurodevelopment deficit was observed in offspring up to 24 months old from mothers who had gestational SCH. |
| Databáze: | OpenAIRE |
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