Short-term hormone therapy improves sCD40L and endothelial function in early menopausal women: potential role of estrogen receptor polymorphisms

Autor:	Sophia N. Kalantaridou, Odysseas Papanikolaou, Patra Vezyraki, Katerina K. Naka, Konstantina Gartzonika, Konstantinos Vakalis, Ioannis Georgiou, Anthoula Chatzikyriakidou, Lampros K. Michalis, Anestis Mavridis, Aris Bechlioulis, Apostolos Kaponis
Rok vydání:	2011
Předmět:	Adult medicine.medical_specialty Endothelium Brachial Artery Genotype medicine.medical_treatment CD40 Ligand Estrogen receptor Inflammation Blood Pressure Severity of Illness Index General Biochemistry Genetics and Molecular Biology medicine.artery Internal medicine Medicine Humans Brachial artery Alleles Progesterone Polymorphism Genetic Vasomotor Estradiol business.industry Estrogen Replacement Therapy Estrogen Receptor alpha Obstetrics and Gynecology Estrogens Cholesterol LDL Middle Aged medicine.disease Menopause Vasodilation P-Selectin Endocrinology medicine.anatomical_structure Blood pressure Hot Flashes Female Hormone therapy Endothelium Vascular medicine.symptom Inflammation Mediators Progestins business Cell Adhesion Molecules Biomarkers
Zdroj:	Maturitas. 71(4)
ISSN:	1873-4111
Popis:	OBJECTIVE: Hormone therapy (HT) has been suggested to improve vascular function and inflammation in menopausal women, although not consistently. We aimed to investigate the effects of HT on endothelial function and inflammation, especially sCD40L, in early menopausal women, and the effect of common estrogen receptor (ER) polymorphisms on vascular responses to HT. STUDY DESIGN: Eighty-four early menopausal women (C and XbaI 454-351A>G) and ERbeta (AluI 1730A>G) were also assessed. RESULTS: The two groups did not differ at baseline. Following HT, vasomotor complaints' severity, blood pressure, LDL, sCD40L, sICAM and sP-Selectin decreased and FMD increased compared to controls (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85c138372977b1253d5cc7f46a69473 https://pubmed.ncbi.nlm.nih.gov/22277987 Zobrazit plný text záznamu Full Text from ScienceDirect