Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions
| Autor: | Yutaka Kanda, Takayuki Nakashima, Masami Kaneko, Mitsunobu Hara, Yuko Uosaki, Shun-Ichi Ikeda |
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| Rok vydání: | 2001 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Apoptosis Inhibitory postsynaptic potential Biochemistry Chemical synthesis Structure-Activity Relationship Neoplasms Drug Discovery Humans Molecular Biology chemistry.chemical_classification Antibiotics Antineoplastic Organic Chemistry Glycoside Antimicrobial In vitro Anti-Bacterial Agents Aminoglycosides Proto-Oncogene Proteins c-bcl-2 chemistry Cell culture Caspases Molecular Medicine Female Function (biology) Lactone HeLa Cells |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:887-890 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)00094-4 |
| Popis: | Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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