High-b diffusivity of MS lesions in cervical spinal cord using ultrahigh-b DWI (UHb-DWI)
| Autor: | John W. Rose, Eun Kee Jeong, Noel G. Carlson, Nabraj Sapkota, Bijaya Thapa, You-Jung Lee, Erica F Bisson, Kyle Jeong, Lubdha M. Shah |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ultra-high B diffusion-weighted imaging
MRI Magnetic resonance imaging IAF Intra-axonal fraction NAWM Normal-Appearing White Matter T2WI T2-weighted imaging 0302 clinical medicine Nuclear magnetic resonance T1WI T1-weighted imaging Medicine FA Fractional anisotropy 2PSM Secondary progressive multiple sclerosis 05 social sciences Diffusion-weighted imaging DWI Regular Article White Matter UHb-rDWI Ultrahigh-b radial DWI medicine.anatomical_structure Spinal Cord Neurology IA Intra-axonal GM Gray matter WM White matter EA Extra-axonal Cognitive Neuroscience Computer applications to medicine. Medical informatics R858-859.7 DTI Diffusion tensor imaging IRB Institutional review board Diffusion tensor imaging DTI CSC Cervical spinal cord Thermal diffusivity 050105 experimental psychology Multiple sclerosis White matter 03 medical and health sciences DH High-b diffusion coefficient Animals Humans rDWI Radial DWI 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging RC346-429 RRMS Relapsing-remitting multiple sclerosis ComputingMethodologies_COMPUTERGRAPHICS business.industry Gender distribution Cervical Cord DWI Diffusion weighted imaging GD Diffusion Gradient Cervical spinal cord 2D ss-DWSTEPI-rFOV 2D Single Shot DW Stimulated EPI with reduced FOV medicine.disease Spinal cord Posterior column MS Multiple Sclerosis Diffusion Magnetic Resonance Imaging UHb Ultrahigh-b Corticospinal tract Array coil 2D single-shot-DW-stimulated-EPI with reduced-FOV (2D ss-DWSTEPI-rFOV) Neurology. Diseases of the nervous system Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 30, Iss, Pp 102610-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Graphical abstract Highlights • Ultrahigh-b DWI (UHb-DWI) method applied to MS spinal cords. • UHb-DWI provides quantitative measures of the MS lesions in the spinal cord. • High-b diffusion coefficient (DH) is theoretically sensitive for demyelination. • DH in MS lesion is significantly elevated compared to that of normal spinal cords. Purpose The purpose of this study was to investigate UHb-rDWI signal in white matter tracts of the cervical spinal cord (CSC) and compare quantitative values between healthy control WM with both MS NAWM and MS WM lesions. Methods UHb-rDWI experiments were performed on (a) 7 MS patients with recently active or chronic lesions in CSC and on (b) 7 healthy control of similar age range and gender distribution to MS subjects. All MRI data were acquired using clinical 3T MRI system. Axial high-b diffusion images were acquired using 2D single-shot DW stimulated EPI with reduced FOV and a CSC-dedicated 8 channel array coil. High-b diffusion coefficient DH was estimated by fitting the signal-b curve to a double or single-exponential function. Results The high-b diffusivity DH values were measured as (0.767 ± 0.297) × 10−3 mm2/s in the posterior column lesions, averaged over 6 MS patients, and 0.587 × 10−3 mm2/s in the corticospinal tract for another patient. The averaged DH values of the 7 healthy volunteers from the posterior and lateral column were (0.0312 ± 0.0306) × 10−3 and (0.0505 ± 0.0205) × 10−3 mm2/s, respectively. UHb-rDWI signal-b curves of the MS patients revealed to noticeably behave differently to that of the healthy controls. The patient signal-b curves decayed with greater high-b decay constants to reach lower signal intensities relative to signal-b curves of the healthy controls. Conclusion UHb-DWI of the CSC reveals a marked difference in signal-b-curves and DH values in MS lesions compared to NAWM and healthy control WM. Based on physical principles, we interpret these altered observations of quantitative diffusion values to be indicative of demyelination. Further studies in animal models will be required to fully interpret UHb-DWI quantitative diffusion values during demyelination and remyelination. |
| Databáze: | OpenAIRE |
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