The value of abdominal ultrasonography compared to colonoscopy and faecal calprotectin in following up paediatric patients with ulcerative colitis
| Autor: | Dorin Farcău, Otilia Fufezan, Oana Serban, Sorin Man, Daniela Elena Serban, Dan L. Dumitrascu, Ioana Fodor, Carmen Asavoaie |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Acoustics and Ultrasonics Concordance Colonoscopy Gastroenterology Severity of Illness Index 03 medical and health sciences Feces 0302 clinical medicine Internal medicine Abdomen medicine Humans Radiology Nuclear Medicine and imaging Child Pathological Retrospective Studies Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Retrospective cohort study Hypervascularity medicine.disease Faecal calprotectin Ulcerative colitis 030104 developmental biology Abdominal ultrasonography 030211 gastroenterology & hepatology Colitis Ulcerative business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Medical ultrasonography. 23(2) |
| ISSN: | 2066-8643 |
| Popis: | Aim: To evaluate the value of abdominal ultrasonography (US) in the follow-up of paediatric patients with ulcerative colitis (UC) compared to faecal calprotectin (FC) and colonoscopy. Material and method: In this retrospective study we enrolled 30 paediatric patients previously diagnosed with UC, examined by abdominal US and colonoscopy within the same week. FC was also determined during the same week. Disease activity was established using the paediatric ulcerative colitis activity index (PUCAI). The global endoscopic activity was evaluated using the Mayo endoscopic subscore. Results: Endos-copy revealed pathological findings of active disease in 27 out of 30 patients; 3 patients were in endoscopic remission. Only 18 of them had clinical active disease (PUCAI >10), [sensitivity (Se) 66.7% and specificity (Sp) 33% of PUCAI in detecting endoscopic active disease). Twenty-three (76.7%) patients had FC >250 mcg/g, but in 2 of these cases the colonoscopy was normal (Se 77.8% and Sp 33.3% in detecting active disease). At US examination, pathological findings (increased bowel wall thickness, hypervascularity, lymphadenopathies, and/or mesenteric inflammatory fat) were found in 27 patients (90%), all with endoscopic active disease (agreement US - colonoscopy, at patient level, k=1.0, p250 mcg/g (85.1%). The inter-observer agreement for the US measurements had an overall ICC of 0.926 with p |
| Databáze: | OpenAIRE |
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