Evidence for preserved insulin responsiveness in the aging rat brain

Autor:	Matthew G. Engel, Jeremy Smith, Kai Mao, Gabriela Farias Quipildor, Min-Hui Cui, Maria Gulinello, Craig A. Branch, Samuel E. Gandy, Derek M. Huffman
Rok vydání:	2022
Předmět:	Male Aging Animals Insulin Brain Geriatrics and Gerontology Insulin Resistance Hippocampus Rats
Zdroj:	GeroScience. 44(5)
ISSN:	2509-2723
Popis:	Insulin appears to exert salutary effects in the central nervous system (CNS). Thus, brain insulin resistance has been proposed to play a role in brain aging and dementia but is conceptually complex and unlikely to fit classic definitions established in peripheral tissues. Thus, we sought to characterize brain insulin responsiveness in young (4–5 months) and old (24 months) FBN male rats using a diverse set of assays to determine the extent to which insulin effects in the CNS are impaired with age. When performing hyperinsulinemic-euglycemic clamps in rats, intracerebroventricular (ICV) infusion of insulin in old animals improved peripheral insulin sensitivity by nearly two-fold over old controls and comparable to young rats, suggesting preservation of this insulin-triggered response in aging per se (p p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84678ad8c25e0ec8daf3e0cf5973158 https://pubmed.ncbi.nlm.nih.gov/35798912 Zobrazit plný text záznamu Full text from SpringerLink