C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase

Autor:	Sherrie L. Pietranico, Ping Wang, Nicholas John Silvester Huby, Mary-Lou Gubler, Louise H. Foley, Weiya Yun, John Vermeulen, Stanley Wertheimer, Gwendolyn Ramsey, Pete William Dunten, Katherine Toth
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Models Molecular Bicyclic molecule Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Lyase Biochemistry Chemical synthesis Sulfonamide chemistry.chemical_compound Cytosol chemistry Amide Xanthines Drug Discovery Molecular Medicine Humans Phosphoenolpyruvate Carboxykinase (GTP) Enzyme Inhibitors Phosphoenolpyruvate carboxykinase Molecular Biology Derivative (chemistry) Alkyl
Zdroj:	Bioorganicmedicinal chemistry letters. 17(14)
ISSN:	0960-894X
Popis:	New modifications on the C-8 4-aminobenzyl unit of the previously reported 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most active compound reported here is the 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with an IC{sub 50} of 0.29 {+-} 0.08 {mu}M. An X-ray analysis of a heteroaromatic sulfonamide is presented showing a new {pi}-{pi} interaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f839692387a725882496d7a69df64713 https://pubmed.ncbi.nlm.nih.gov/17532214 Zobrazit plný text záznamu Full Text from ScienceDirect