Tumor-specific recombinant idiotype immunisation after chemotherapy as initial treatment for follicular non-Hodgkin lymphoma
| Autor: | John M. Timmerman, Julie M. Vose, Ronald Levy, Dan W. Denney, Wen-Kai Weng, Martha Mayo, Debra K. Czerwinski, Diane E. Ingolia |
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| Rok vydání: | 2009 |
| Předmět: |
Idiotype
Adult Male Cancer Research medicine.medical_treatment Follicular lymphoma Antineoplastic Agents Active immunotherapy Cancer Vaccines Immunoglobulin Idiotypes Medicine Humans Lymphoma Follicular B cell Aged Neoplasm Staging biology business.industry Immunogenicity Hematology Immunotherapy Middle Aged medicine.disease Recombinant Proteins Lymphoma Survival Rate medicine.anatomical_structure Treatment Outcome Oncology Immunology biology.protein Disease Progression Female Immunization business Keyhole limpet hemocyanin Follow-Up Studies |
| Zdroj: | Leukemialymphoma. 50(1) |
| ISSN: | 1029-2403 |
| Popis: | Tumor-specific variable regions of the clonal immunoglobulin (idiotype, Id) expressed by B cell non-Hodgkin lymphoma (NHL) can be targeted by active immunotherapy. We conducted a phase I/II trial to determine the safety and immunogenicity of a patient-specific, recombinant, mammalian cell-derived Id protein conjugated to keyhole limpet hemocyanin (Id-KLH; MyVax® personalised immunotherapy) in 22 patients with follicular NHL in first remission after chemotherapy. Subjects received five subcutaneous immunisations with MyVax® plus locally administered granulocyte-macrophage colony-stimulating factor (GM-CSF). Among 21 evaluable patients, 62% mounted Id-specific immune responses. Evoked anti-Id antibodies recognised both recombinant Id and native Id, and could specifically stain autologous tumor cells. At median follow-up of more than 6 years, median progression-free survival is 38 months. Immunisation of follicular lymphoma patients with MyVax® Id-KLH is safe and patients often mount tumor-specific immune responses. These results form the basis of a pivotal phase 3 trial of MyVax® in follicular NHL. |
| Databáze: | OpenAIRE |
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