Significance of liquid biopsy in glioblastoma - A review
| Autor: | Zsuzsanna Birkó, Almos Klekner, László Szivos, László Bognár, Bálint Nagy, József Virga, Péter Árkosy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Oncology Male medicine.medical_specialty Bioengineering Disease Klinikai orvostudományok Exosomes 01 natural sciences Applied Microbiology and Biotechnology Extracellular vesicles 03 medical and health sciences Extracellular Vesicles 010608 biotechnology Internal medicine medicine Biomarkers Tumor Humans Liquid biopsy Aged Aged 80 and over business.industry Clinical course Liquid Biopsy Effective management Orvostudományok General Medicine Radiological examination medicine.disease Review article 030104 developmental biology Female business Glioblastoma Cell-Free Nucleic Acids Biotechnology |
| Zdroj: | Journal of biotechnology. 298 |
| ISSN: | 1873-4863 |
| Popis: | Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumor with a 16-24 -months overall survival time (OS). Effective management is hindered by intratumoral heterogeneity, a characteristic trait of GBM which results in subpopulations of cells with altered therapeutic responsiveness, different invasiveness and growth potential. Correct initial molecular profiling of the tumor, as well as following its molecular biological changes are further impeded by the intracranial location of the tumors, hence the risks of surgical interventions. Radiological examination, the sole non-invasive method of obtaining information about the tumors, also has limitations. This review article aims to summarize the currently available information about the promising applicability of liquid biopsy, extracellular vesicles (EVs), and circulating cell-free nucleic acids (cf-NAs) in GBM patients. Liquid biopsy is a quick and inexpensive way of obtaining exceptionally relevant information about tumors, and can be performed multiple times during the clinical course of the disease. Furthermore, integrating analyses of EVs and related cf-NAs in clinical practice might also help to establish diagnosis in a non-invasive manner, and complex oncotherapy could be indicated in the future without high-risk neurosurgical interventions. |
| Databáze: | OpenAIRE |
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