Pharmacokinetic Evaluation of Single-Dose Intravenous Daptomycin in Patients with Thermal Burn Injury
| Autor: | David J. Wainright, Donald H. Parks, Luis Ostrosky-Zeichner, Timothy C. Hollenbeck, John F. Mohr, Charles D. Ericsson |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate medicine.drug_class Antibiotics Clinical Therapeutics Body weight Daptomycin Pharmacokinetics medicine Humans Pharmacology (medical) In patient Chromatography High Pressure Liquid Antibacterial agent Pharmacology Volume of distribution business.industry Middle Aged Thermal burn Anti-Bacterial Agents Surgery Infectious Diseases Area Under Curve Anesthesia Female Burns business medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 52:1891-1893 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01321-07 |
| Popis: | Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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