The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals
| Autor: | J.J.N. Costa, Robert van den Hurk, A. W. B. Silva, Márcia Viviane Alves Saraiva, José Vieira Silva, R.O.D.S. Rossi |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty GDF2 Biology Bone morphogenetic protein Bone morphogenetic protein 2 03 medical and health sciences Oogenesis Internal medicine medicine Animals Bone morphogenetic protein receptor Mammals Bone morphogenetic protein 15 Ovary Bone morphogenetic protein 10 Bone Morphogenetic Protein Receptors Cell Biology BMPR2 Cell biology 030104 developmental biology Endocrinology GDF6 Bone Morphogenetic Proteins Female Signal Transduction Developmental Biology |
| Zdroj: | Zygote. 24:1-17 |
| ISSN: | 1469-8730 0967-1994 |
| Popis: | SummaryThe bone morphogenetic protein (BMP) family consists of several growth factor proteins that belong to the transforming growth factor-β (TGF-β) superfamily. BMPs bind to type I and type II serine–threonine kinase receptors, and transduce signals through the Smad signalling pathway. BMPs have been identified in mammalian ovaries, and functional studies have shown that they are involved in the regulation of oogenesis and folliculogenesis. This review summarizes the role of the BMP system during formation, growth and maturation of ovarian follicles in mammals. |
| Databáze: | OpenAIRE |
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