The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis
| Autor: | B. Paul Wordsworth, Gordon W. Duff, Andrei Calin, Owen Beynon, Aaron Abbott, Anne Marie Sims, A. M. Crane, Linda A. Bradbury, Ibi Herzberg, Heather J. Cordell, Andrew E. Timms, Lon R. Cardon, Matthew A. Brown, Mark R.E. Coyne |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Genotype
DNA Mutational Analysis Inheritance Patterns Single-nucleotide polymorphism Human leukocyte antigen Biology Polymorphism Single Nucleotide Gene Frequency Gene cluster Genetics medicine Humans Genetics(clinical) Genetic Predisposition to Disease Spondylitis Ankylosing Spondylitis HLA-B27 Antigen Genetics (clinical) DNA Primers Electrophoresis Agar Gel Ankylosing spondylitis Haplotype Interleukin Articles medicine.disease Major gene United Kingdom Haplotypes Chromosomes Human Pair 2 Immunology Interleukin-1 |
| Popis: | Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS. |
| Databáze: | OpenAIRE |
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