Controversies in the therapeutic approach to congenital cytomegalovirus infection
| Autor: | Juan Arnaez, Maria Garrido-Barbero, Alfredo García-Alix |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Pediatrics medicine.medical_specialty 030106 microbiology Cytomegalovirus Antiviral Agents 03 medical and health sciences Therapeutic approach 0302 clinical medicine Cerebrospinal fluid medicine Humans Valganciclovir 030212 general & internal medicine medicine.diagnostic_test business.industry Infant Newborn Brain Infant Magnetic resonance imaging General Medicine Magnetic Resonance Imaging Infectious Diseases Spain Cytomegalovirus Infections Female business beta 2-Microglobulin |
| Zdroj: | Infection. 48(3) |
| ISSN: | 1439-0973 |
| Popis: | Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection admitted to our neonatal unit between 2015 and 2019, half showed paucisymptomatic neurological manifestations. In these cases, the determination of s2-microglobulin in cerebrospinal fluid and magnetic resonance imaging aided in the decision-making concerning the therapeutic approach to follow. |
| Databáze: | OpenAIRE |
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