Clinical significance of angiopoietin-like protein 4 expression in tissue and serum of esophageal squamous cell carcinoma patients
| Autor: | Lei Xiong, Banzhou Pan, Hai-zhu Song, Jun Yi |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cancer Research Esophageal Neoplasms Angiogenesis Angiopoietin-like protein 4 Disease-Free Survival Metastasis ANGPTL4 Esophageal squamous cell carcinoma Diagnosis medicine Humans Clinical significance Tumor marker Aged Aged 80 and over Original Paper Esophageal disease business.industry Area under the curve General Medicine Hematology Middle Aged medicine.disease Prognosis Up-Regulation ROC Curve Oncology Lymphatic Metastasis Carcinoma Squamous Cell Immunohistochemistry Female business Angiopoietins |
| Zdroj: | Medical Oncology (Northwood, London, England) |
| ISSN: | 1357-0560 |
| DOI: | 10.1007/s12032-013-0680-y |
| Popis: | Angiopoietin-like protein 4 (ANGPTL4) has been reported to promote tumor growth, metastasis, and angiogenesis under certain conditions. The aim of this study was to examine ANGPTL4 expression in tumor and serum tissues from esophageal squamous cell carcinoma (ESCC) patients. A total of 78 ESCC patients treated with radical resection were enrolled in this study. Immunohistochemistry was used to detect ANGPTL4 expression in ESCC tissues. Serum ANGPTL4 levels were determined via enzyme-linked immunosorbent assay (ELISA). The receiver operating characteristics curve was constructed to describe diagnostic specificity and sensitivity. There were 52 cases (69.2 %) showing a higher level of ANGPTL4 expression in tumor tissues than that in normal tissues, and the rate of ANGPTL4 protein high/moderate expression in ESCC and normal tissues was 55.1 % (43/78) and 6.4 % (5/78), respectively, with a significant difference (P |
| Databáze: | OpenAIRE |
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