Chitinase: diversity, limitations, and trends in engineering for suitable applications
| Autor: | Yahaya M. Normi, Ayokunmi Oyeleye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Models Molecular chitooligosaccharides Computer science Protein Conformation Biophysics Chitin Review Article Biochemistry Substrate Specificity 03 medical and health sciences chemistry.chemical_compound Animals Humans biocontrol Pest Control Biological Molecular Biology Review Articles biology variability fungi Chitinases protein engineering Cell Biology 030104 developmental biology chemistry Chitinase biology.protein Biochemical engineering Biotechnology |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin for the production of industrially useful products and in the control of fungal pathogens and insect pests render them attractive for such purposes. However, chitinases have diverse sources, characteristics, and mechanisms of action that seem to restrain optimization procedures and render standardization techniques for enhanced practical applications complex. Hence, results of laboratory trials are not usually consistent with real-life applications. With the growing field of protein engineering, these complexities can be overcome by modifying or redesigning chitinases to enhance specific features required for specific applications. In this review, the variations in features and mechanisms of chitinases that limit their exploitation in biotechnological applications are compiled. Recent attempts to engineer chitinases for improved efficiency are also highlighted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|