The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais
| Autor: | Amonrat Jumnainsong, Amornrat Romphruk, Suwit Chaisri, Chanvit Leelayuwat |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) medicine.medical_specialty Adolescent 030106 microbiology Immunology Human leukocyte antigen Severity of Illness Index Dengue fever Dengue Young Adult 03 medical and health sciences Immune system Medical microbiology Receptors KIR HLA Antigens T-Lymphocyte Subsets Genotype medicine Humans Immunology and Allergy Receptor Polymorphism Genetic Innate immune system business.industry General Medicine Odds ratio Thailand medicine.disease Killer Cells Natural 030104 developmental biology Case-Control Studies Disease Susceptibility business |
| Zdroj: | Medical Microbiology and Immunology. 209:613-620 |
| ISSN: | 1432-1831 0300-8584 |
| DOI: | 10.1007/s00430-020-00685-z |
| Popis: | Killer cell immunoglobulin-like receptors (KIRs) are cell surface receptors on natural killer (NK) cells and subsets of T cells. The interaction between KIRs and their cognate ligands (Human leukocyte antigen class I molecules, HLA class I) modulates the immune response of NK cells, in particular through clearance of virus-infected cells. Here, we investigated the effect of KIRs and HLA ligands on dengue infections and disease severity. The KIRs and HLA ligands were identified in 235 healthy controls (HC) and 253 dengue patients (DEN) using polymerase chain reaction with sequence specific primer (PCR–SSP); moreover, DEN was classified to 100 dengue fever (DF) and 153 dengue haemorrhagic fever (DHF). Risks were expressed as odds ratios (ORs) and 95% confidence intervals (CIs) with significance set at a two-tailed P value of |
| Databáze: | OpenAIRE |
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