Correlation Between Biofilm Formation and Antibiotic Resistance in MRSA and MSSA Isolated from Clinical Samples in Iran: A Systematic Review and Meta-Analysis
| Autor: | Motahare-Sadat Hosseini, Abbas Shapouri Moghaddam, Mehdi Hadadi-Fishani, Solmaz Derakhshan, Aliyar Pirouzi, Seyed Mohammad Amin Hashemipour, Azad Khaledi |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Coagulase Methicillin-Resistant Staphylococcus aureus Staphylococcus aureus Immunology Gene Expression Drug resistance Microbial Sensitivity Tests Iran medicine.disease_cause Microbiology 03 medical and health sciences Methicillin Antibiotic resistance medicine Prevalence Humans 030304 developmental biology Pharmacology 0303 health sciences 030306 microbiology Mesh term business.industry Biofilm biochemical phenomena metabolism and nutrition Staphylococcal Infections Methicillin-resistant Staphylococcus aureus Antimicrobial drug Anti-Bacterial Agents Meta-analysis Biofilms Methicillin Resistance business |
| Zdroj: | Microbial drug resistance (Larchmont, N.Y.). 26(9) |
| ISSN: | 1931-8448 |
| Popis: | Objectives: This study aimed at reviewing the correlation between biofilm formation and antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) isolates. Materials and Methods: This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. The literature search was conducted in PubMed, Web of Science (ISI), and Scopus databases. Combinations of Mesh terms such as "biofilms" OR "biofilm formation," AND "Drug Resistance" OR "Antimicrobial Drug Resistance" OR "Antibiotic Resistance" AND "Staphylococcus aureus" OR "Methicillin-resistant Staphylococcus aureus" or "MRSA" AND "Methicillin-sensitive Staphylococcus aureus" OR "MSSA" AND "biofilm-related genes" AND "Prevalence" AND "Iran" were searched. Two reviewers independently searched the databases. Analyses were performed in Comprehensive Meta-Analysis software. The random-effects model was used to obtain the combined prevalence with a 95% confidence interval (CI). Results: The combined prevalence of MRSA retrieved from Iranian clinical samples was 48.3% (95% CI: 40.8-55.9). The pooled rate of biofilm formation in MRSA strains was reported as 80.9% (95% CI: 67.8-89.4). Overall, 52.9%, 45.3%, and 22.5% of MRSA isolates were strong, moderate, and weak biofilm producers, respectively. The highest frequency of biofilm-related genes was observed for icaD gene (67.7%) followed by clfA gene with a frequency of 64.7%. Among seven studies that addressed the relationship between biofilm formation and antibiotic resistance, six reported positive associations. Conclusions: Regarding the MRSA strains, they had a significantly higher ability of biofilm formation than MSSA strains; therefore, preventive measures against infections caused by them are required. |
| Databáze: | OpenAIRE |
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