Uncommon Case of Oral Vancomycin Neurotoxicity With Sexual Dysfunction
| Autor: | Omar Shahada, Ahmed S Almohammadi, Muath Alqayidi, Abdulhadi Z Almadani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment vancomycin Infectious Disease 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine neurotoxicity Internal Medicine medicine Toxication Past medical history business.industry General Engineering Type 2 Diabetes Mellitus Pseudomembranous colitis clostridium difficile Clostridium difficile Sexual dysfunction Neurology chemistry sexual dysfunction Vancomycin Hemodialysis medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.12396 |
| Popis: | We report a case of a 57-year-old male with a past medical history of controlled hypertension and type 2 diabetes mellitus, who had unusual elevated serum concentration levels of vancomycin during oral treatment for Clostridium difficile pseudomembranous colitis. Both measured serum vancomycin levels of 39 μg/ml and cerebrospinal fluid level of 5.7 μg/mL were documented and associated with unexplained neurological symptoms and sexual dysfunction. After discontinuing of oral vancomycin and treating with hemodialysis, the patient had reduced serum concentration levels to 26 μg/mL accompanied by significant and rapid resolution of symptoms in addition to the general condition. Patients with intestinal disease and reduced renal function who are being treated with oral vancomycin may absorb and accumulate high serum level amounts of vancomycin, causing uncommon neurological toxication symptoms including headache, altered state of consciousness, confusion, and drowsiness in association with sexual dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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