Association between Toxoplasma gondii Infection and Nephrotic Syndrome Risk in Children: A Case–Control Study and Systematic Review

Autor:	Hadi Sorkhi, Abolfazl Mollalo, Ali Bijani, Saeed Mehravar, Mohammad Pournasrollah, Sahar Sadr Moharerpour, Ali Rostami
Rok vydání:	2022
Předmět:	Nephrotic Syndrome Antibodies Protozoan Enzyme-Linked Immunosorbent Assay Observational Studies as Topic Infectious Diseases Immunoglobulin M Seroepidemiologic Studies Case-Control Studies Immunoglobulin G Pediatrics Perinatology and Child Health Humans Child Toxoplasma Toxoplasmosis
Zdroj:	Journal of Tropical Pediatrics. 68
ISSN:	1465-3664 0142-6338
Popis:	Some evidence suggests toxoplasmosis as an etiology of nephrotic syndrome (NS) in children; however, no observational study evaluated this relationship. In a case–control study, we enrolled 35 children with NS and 37 healthy children. All participants were examined for anti-Toxoplasma immunoglobulin G and M (IgG and IgM) antibodies using enzyme-linked immunosorbent assay. We also systematically reviewed the literature to assess this relationship. Prevalence of anti-Toxoplasma IgG was 17.4% and 13.5% in cases and controls, respectively, indicating a non-significant association (adjusted odds ratio, 1.22, 95% confidence interval, 0.35–4.41). No subjects were seropositive for IgM. In a systematic review, we found that acute toxoplasmosis can induce NS in some children and anti-Toxoplasma treatment is effective in the remission of NS in these cases. In pediatrics with NS, acute toxoplasmosis should be considered as a neglected causative factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73a2f1b5c58316dabb4ed0525a62998 https://doi.org/10.1093/tropej/fmac067 Zobrazit plný text záznamu