The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage
| Autor: | Yi Hsiu Chen, Hitoshi Shirakawa, Suh Ching Yang, Qian Xiao, Hsiang Chi Peng, Satwika Arya Pratama, Ya Ling Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Glutamine Muscle Proteins Inflammation Article chemistry.chemical_compound microbiota composition muscle protein degradation Internal medicine medicine Animals TX341-641 Liver damage Intestinal Mucosa Rats Wistar glutamine muscle protein synthesis gut permeability ethanol-induced liver injury Wistar rats Liver Diseases Alcoholic Liver injury Nutrition and Dietetics Intestinal permeability Ethanol Nutrition. Foods and food supply Chemistry Hyperammonemia medicine.disease Rats Disease Models Animal Endocrinology Liver Protein Biosynthesis Dietary Supplements Proteolysis Liver function medicine.symptom Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 2788, p 2788 (2021) Nutrients; Volume 13; Issue 8; Pages: 2788 |
| ISSN: | 2072-6643 |
| Popis: | The purpose of this research was to investigate the prophylactic effects of glutamine on muscle protein synthesis and degradation in rats with ethanol-induced liver injury. For the first 2 weeks, Wistar rats were divided into two groups and fed a control (n = 16) or glutamine-containing diet (n = 24). For the following 6 weeks, rats fed the control diet were further divided into two groups (n = 8 per group) according to whether their diet contained no ethanol (CC) or did contain ethanol (CE). Rats fed the glutamine-containing diet were also further divided into three groups (n = 8 per group), including a GG group (glutamine-containing diet without ethanol), GE group (control diet with ethanol), and GEG group (glutamine-containing diet with ethanol). After 6 weeks, results showed that hepatic fatty change, inflammation, altered liver function, and hyperammonemia had occurred in the CE group, but these were attenuated in the GE and GEG groups. Elevated intestinal permeability and a higher plasma endotoxin level were observed in the CE group, but both were lower in the GE and GEG groups. The level of a protein synthesis marker (p70S6K) was reduced in the CE group but was higher in both the GE and GEG groups. In conclusion, glutamine supplementation might elevate muscle protein synthesis by improving intestinal health and ameliorating liver damage in rats with chronic ethanol intake. |
| Databáze: | OpenAIRE |
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