Relationship between matrix metalloproteinase-9 and oxidative stress in drug-free male schizophrenia: a case control study
| Autor: | Shivanand Kattimani, Hanumanthappa Nandeesha, Sivasankar Devanarayanan, Siddharth Sarkar |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Disease medicine.disease_cause Models Biological Lipid peroxidation Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Malondialdehyde medicine Humans Positive and Negative Syndrome Scale business.industry Biochemistry (medical) Case-control study General Medicine 030227 psychiatry Oxidative Stress Endocrinology chemistry Matrix Metalloproteinase 9 Case-Control Studies Synaptic plasticity Linear Models Schizophrenia business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Clinical chemistry and laboratory medicine. 54(3) |
| ISSN: | 1437-4331 |
| Popis: | Deregulation of synaptic plasticity and oxidative stress are reported to play a crucial role in the pathogenesis of schizophrenia. Matrix metalloproteinase-9 (MMP-9) is an extracellular protease involved in regulation of synaptic plasticity. Malondialdehyde (MDA) is a marker of lipid peroxidation which is elevated in schizophrenia. Earlier studies have reported polymorphism of MMP-9 and its association with schizophrenia. The present study was designed to assess the serum levels of MMP-9, MDA and total antioxidant status (TAS) and their association in schizophrenia.A total of 40 cases and 40 controls were included in the study. Serum MMP-9, MDA and TAS were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS).MMP-9 and MDA were significantly increased and TAS were significantly reduced in schizophrenia cases compared to controls. MMP-9 was positively correlated with MDA (r=0.353, p=0.025) and negatively correlated with TAS (r=−0.461, p=0.003). TAS was significantly correlated with total (r=0.322, p=0.043) and negative symptom scores (r=0.336, p=0.034). Higher MMP-9 levels were associated with previous exposure to antipsychotics (p=0.032).MMP-9 and oxidative stress were increased and correlate well with each other in schizophrenia cases. Though total oxidant status showed positive association with disease severity, MMP-9 and MDA were not associated with the severity of the disease. |
| Databáze: | OpenAIRE |
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