Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statins
| Autor: | Christos Papamichael, Dimitrios J. Tryfonopoulos, Theodoros G. Papaioannou, Kimon Stamatelopoulos, Anna G. Dagre, John Lekakis, Myron Mavrikakis, Athanassios D. Protogerou, Stamatios F. Stamatelopoulos |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Brachial Artery Endothelium Epidemiology Hypercholesterolemia Administration Oral Blood lipids Placebo Gastroenterology law.invention Coronary artery disease Folic Acid Double-Blind Method Randomized controlled trial Oral administration law Internal medicine medicine.artery medicine Humans Brachial artery Aged Ultrasonography business.industry Middle Aged medicine.disease Surgery Vasodilation Clinical trial medicine.anatomical_structure Regional Blood Flow Dietary Supplements Hematinics Female Endothelium Vascular Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Cardiovascular Prevention & Rehabilitation. 11:416-420 |
| ISSN: | 1741-8267 |
| DOI: | 10.1097/00149831-200410000-00010 |
| Popis: | Background Folic acid therapy has been shown to improve endothelial function in patients with familial hypercholesterolaemia via a possible antioxidant mechanism. Data on the possible role of folic acid in hypercholesterolaemic patients receiving statins are lacking. In the present study we tested the hypothesis that folic acid supplementation improves endothelial function in patients with hypercholesterolaemia and treatment with statins. Methods Thirty-four hypercholesterolaemic patients receiving statins participated in the study; all subjects underwent measurement of endothelium-dependent, flow-mediated dilatation of the brachial artery and subsequently randomized to receive 5 mg of the folic acid (n=17) or placebo (n=17) for 4 weeks. Flow-mediated dilatation of the brachial artery was repeated at the end of the 4-week period. Results Folic acid and placebo groups were comparable regarding age, sex, smoking, hypertension, coronary artery disease, obesity, family history and blood lipids. Folic acid administration resulted in an improvement of flow-mediated dilatation (4.7+/-3.2% to 7.1+/-3.1%, P=0.02), whereas there was no improvement after placebo administration (5.7+/-3.8% to 5.6+/-2.2%, ns). No significant change in nitrate-induced, endothelium- independent dilatation was observed after folic acid or placebo (ns). Conclusions Oral administration of folic acid (5 mg) for 4 weeks improves endothelial function in patients with hypercholesterolaemia treated with statins, with possible beneficial effects on the prognosis of these patients. |
| Databáze: | OpenAIRE |
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