Changes in Autonomic Tone in Premature Infants Developing Necrotizing Enterocolitis
| Autor: | Adre J. du Plessis, Mariam Said, Anthony D. Sandler, Rathinaswamy B. Govindan, Caitlin Cristante, Marina Metzler, Dan Reich, Tareq Al-Shargabi, Somya Shankar, Robert McCarter |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Infant Premature Diseases Autonomic Nervous System Electrocardiography 03 medical and health sciences 0302 clinical medicine Enterocolitis Necrotizing Heart Rate 030225 pediatrics Internal medicine medicine Humans Heart rate variability Depression (differential diagnoses) Enterocolitis Receiver operating characteristic business.industry Mortality rate Infant Newborn Obstetrics and Gynecology medicine.disease digestive system diseases Autonomic nervous system Logistic Models ROC Curve Case-Control Studies Pediatrics Perinatology and Child Health Necrotizing enterocolitis Cardiology Female medicine.symptom Complication business Biomarkers Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Perinatology. 35:1079-1086 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-0038-1639339 |
| Popis: | Background Necrotizing enterocolitis (NEC) is a complication of prematurity with a high mortality rate. Currently, there are no reliable biomarkers capable of identifying infants at risk for developing NEC. We sought to determine the autonomic nervous system antecedents of NEC in premature infants, using heart rate variability (HRV). Materials and Methods HRV was quantified by retrieving archived electrocardiogram (EKG) data from 30 premature infants from 4 days prior, through 4 days after, the clinical NEC diagnosis. HRV metrics were compared with those on the diagnosis day using the receiver operating characteristic (ROC) analysis. Results HRV metrics showed a depression of autonomic tone that preceded the clinical NEC diagnosis by 2 days, and which recovered to baseline by 2 days after diagnosis (area under the curve [AUC] Conclusion Our studies suggest that readily accessible metrics of autonomic depression might expedite the diagnosis of NEC and its severity in a clinically meaningful manner. Clearly, these studies need to be extended prospectively to determine the diagnostic utility of this approach. |
| Databáze: | OpenAIRE |
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