HIV‐1 subtypes and drug resistance in children during antiretroviral therapy in Brazil

Autor: Allan Kardec Barros, Jessyca Kalynne Farias Rodrigues, Antonia Iracilda e Silva Viana, Claudia Regina de Andrade Arrais, Marta de Oliveira Barreiros, Francisco Dimitre Rodrigo Pereira Santos, Kledoaldo Lima, Daniel Duarte Costa, Élcio Leal, Nilviane Pires Silva Sousa, Gerson Fernando Mendes Pereira
Rok vydání: 2021
Předmět:
Zdroj: Journal of Medical Virology. 93:4908-4914
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.26988
Popis: We evaluate the genetic characterization of 132 HIV-1 pol sequences from children and adolescents undergoing antiretroviral therapy in Northeast Brazil. Phylogenetic and recombination analyses were performed using the maximum likelihood method using SeaView version 4 and SIMPLOT software. Most individuals harbored HIV-1 B (84.8%) and BF recombinants (9.8%), although other non-B subtypes were detected: HIV-1 C (1.5%), HIV-1 F (2.4%), and BC recombinants (1.5%). Antiretroviral resistance was 47% (95% confidence interval [CI]: 38.7%-55.4%). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) showed higher frequencies of primary mutations, with 40.9% (95% CI: 32.9%-49.4%), followed by nucleoside reverse transcriptase inhibitors (NRTI) and protease inhibitors (PIs) with 34.8% (95% CI: 27.3-43.3) and 6.1% (95% CI: 3.1%-11.5%), respectively. Among NRTIs, higher resistance levels were observed for abacavir, emtricitabine, and lamivudine; for NNRTI, nevirapine and efavirenz. The most common primary mutations found were M184V (29.5%), K103N (25%), M41L (9.8%), T215Y (8.3%), and G190A (8.3%). Our findings highlight the importance of surveillance of resistance mutations, which contributes to the continuous updating and implementation of preventive measures to decrease mother-to-child-transmission and transmitted drug resistance.
Databáze: OpenAIRE
Externí odkaz: