In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens
Autor: | D L Shungu, Ellen Weinberg, Hans H. Gadebusch |
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Rok vydání: | 1983 |
Předmět: |
Sulfamethoxazole
Gastrointestinal Diseases Erythromycin Microbial Sensitivity Tests Pharmacology medicine.disease_cause Trimethoprim Microbiology Nalidixic Acid Minimum inhibitory concentration Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Pharmacology (medical) Shigella Norfloxacin Bacteria biology Vibrio parahaemolyticus Drug Resistance Microbial Bacterial Infections biology.organism_classification Anti-Bacterial Agents Drug Combinations Infectious Diseases bacteria Campylobacter fetus Digestive System Research Article medicine.drug |
Zdroj: | Antimicrobial Agents and Chemotherapy. 23:86-90 |
ISSN: | 1098-6596 0066-4804 |
Popis: | A comparison was made of the in vitro activities of norfloxacin and of nine other orally administered antibacterial agents against 180 clinical isolates representing the bacterial species most frequently implicated in infections of the gastrointestinal tract in humans. The 90% minimal inhibitory concentrations showed norfloxacin to be 4, 15, 4, 17, 17, 17, and 33 times more active than the next best compound tested against Campylobacter fetus subsp. jejuni, Escherichia coli, Salmonella spp., Shigella spp., Vibrio cholerae, Vibrio parahaemolyticus, and Yersinia enterocolitica, respectively, with an overall 90% minimal inhibitory concentration of less than or equal to 0.5 micrograms/ml. Norfloxacin was least active against Clostridium difficile (90% minimal inhibitory concentration, 128 micrograms/ml). These results should encourage further evaluation of norfloxacin as a potential chemotherapeutic agent in the treatment of enteric bacterial infections for which antibiotic therapy is indicated. |
Databáze: | OpenAIRE |
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