Histamine Enhances Theta-Coupled Spiking and Gamma Oscillations in the Medial Entorhinal Cortex Consistent With Successful Spatial Recognition
| Autor: | Quanhui Chen, Chao He, Qin Xiao, Jianxia Xia, Jun Jiang, Faguo Yue, Dong Gao, Jun Zhang, Zhian Hu, Bo Hu, Xiang Liao, Fen-Lan Luo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cognitive Neuroscience Biophysics Spatial memory Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Histamine receptor 0302 clinical medicine Histamine Agents Medial entorhinal cortex Animals Entorhinal Cortex Gamma Rhythm Theta Rhythm Wakefulness gamma-Aminobutyric Acid Neurons Dose-Response Relationship Drug Chemistry Histaminergic Grid cell Spatial cognition Synaptic Potentials Electric Stimulation Rats 030104 developmental biology Pattern Recognition Visual Space Perception Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Histamine Photic Stimulation |
| Zdroj: | Cerebral cortex (New York, N.Y. : 1991). 28(7) |
| ISSN: | 1460-2199 |
| Popis: | Encoding of spatial information in the superficial layers of the medial entorhinal cortex (sMEC) involves theta-modulated spiking and gamma oscillations, as well as spatially tuned grid cells and border cells. Little is known about the role of the arousal-promoting histaminergic system in the modification of information encoded in the sMEC in vivo, and how such histamine-regulated information correlates with behavioral functions. Here, we show that histamine upregulates the neural excitability of a significant proportion of neurons (16.32%, 39.18%, and 52.94% at 30 μM, 300 μM, and 3 mM, respectively) and increases local theta (4-12 Hz) and gamma power (low: 25-48 Hz; high: 60-120 Hz) in the sMEC, through activation of histamine receptor types 1 and 3. During spatial exploration, the strength of theta-modulated firing of putative principal neurons and high gamma oscillations is enhanced about 2-fold by histamine. The histamine-mediated increase of theta phase-locking of spikes and high gamma power is consistent with successful spatial recognition. These results, for the first time, reveal possible mechanisms involving the arousal-promoting histaminergic system in the modulation of spatial cognition. |
| Databáze: | OpenAIRE |
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