Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison

Autor: Hafedh Dekhil, Mohammed Faraj Alosaimi, Khalid Siddiqui, Mohamed Rafiullah, Naif Alotaibi, Rana Hasanato, Haifa Altalhi, Assim A. Alfadda, Khalid Alayed, Ibrahim Almaghlouth, Saleh Albanyan, Arthur C. Isnani, Musa Alzahrani, Mohammed Alarifi, Mohammad AlKhowaiter, Amira M. Youssef, Khalifa Binkhamis
Rok vydání: 2021
Předmět:
medicine.medical_treatment
ALP
Alkaline phosphatase
Infectious and parasitic diseases
RC109-216
Comorbidity
medicine.disease_cause
chemistry.chemical_compound
Suspected COVID-19
PTT
Partial thromboplastin time
Blood urea nitrogen
Case report form
Reverse Transcriptase Polymerase Chain Reaction
General Medicine
Hospitalization
ICU
Intensive care unit
Infectious Diseases
Original Article
Public aspects of medicine
RA1-1270
AST
Aspartate aminotransferase
SPSS
Statistical Package for the Social Sciences
Nasal cannula
BUN
Blood urea nitrogen
Adult
medicine.medical_specialty
SARS-CoV-2
Severe acute respiratory syndrome-coronavirus-2
BMI
Body mass index
COVID-19
Coronavirus disease-2019
INR
International normalised ratio
ACE-2
Angiotensin-converting enzyme-2
Internal medicine
ARDS
Acute respiratory distress syndrome
medicine
Carcinoma
Humans
CRP
C-Reactive protein
Mechanical ventilation
Creatinine
LDH
Lactate dehydrogenase
Clinical characteristics
business.industry
RT-PCR
Reverse-transcriptase polymerase chain reaction
SARS-CoV-2
Public Health
Environmental and Occupational Health
ALT
Alanine aminotransferase
Negative RT-PCR
COVID-19
CK
Creatine kinase
medicine.disease
GGT
Gamma-glutamyl transferase
CKD
Chronic kidney disease
PT
Prothrombin time
Blood pressure
chemistry
business
Kidney disease
Zdroj: Journal of Infection and Public Health, Vol 14, Iss 11, Pp 1623-1629 (2021)
Journal of Infection and Public Health
ISSN: 1876-035X
Popis: Background COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive. Methods This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48−72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form. Results The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group. Conclusion Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results.
Databáze: OpenAIRE
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