Personalized transcranial alternating current stimulation (tACS) and physical therapy to treat motor and cognitive symptoms in Parkinson's disease: A randomized cross-over trial
| Autor: | Stefano Masiero, Elena Tenconi, Emanuela Formaggio, Alessandra Del Felice, Bruno Scarpa, Manuela Cattelan, Paolo Manganotti, Leonora Castiglia |
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| Přispěvatelé: | Del Felice, A., Castiglia, L., Formaggio, E., Cattelan, M., Scarpa, B., Manganotti, P., Tenconi, E., Masiero, S. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
NIBS non-invasive brain stimulation Parkinson's disease BDI-II Beck Depression Inventory-II (BDI-II) Electroencephalography Neurophysiology Neurotherapeutic target Non-invasive brain stimulation (NIBS) Unified Parkinson's disease rating scale (UPDRS III) Radiology Nuclear Medicine and Imaging Neurology Neurology (clinical) Cognitive Neuroscience Hypokinesia Transcranial Direct Current Stimulation Severity of Illness Index lcsh:RC346-429 RNS random noise stimulation 0302 clinical medicine Nuclear Medicine and Imaging Outcome Assessment Health Care Medicine Beta Rhythm Precision Medicine Transcranial alternating current stimulation Aged 80 and over GDI Gait Dynamic Index Cross-Over Studies SM sensorimotor area medicine.diagnostic_test FFT fast Fourier Transform 05 social sciences Neuropsychology GDS Geriatric Depression Scale Montreal Cognitive Assessment Regular Article tACS transcranial alternating current stimulation Parkinson Disease PD Parkinson's Disease Middle Aged MCID minimal clinical important difference Combined Modality Therapy MMSE Mini Mental State Examination Exercise Therapy lcsh:R858-859.7 Female Radiology EEG electroencephalography medicine.medical_specialty lcsh:Computer applications to medicine. Medical informatics Breathing Exercises 050105 experimental psychology STAY-Y State-Trait Anxiety Inventory 03 medical and health sciences Double-Blind Method UPDRS III Unified Parkinson's Disease Rating Scale-motor Humans Cognitive Dysfunction 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Effects of sleep deprivation on cognitive performance lcsh:Neurology. Diseases of the nervous system Aged TMT A and B trail making test form A and B business.industry TMS transcranial magnetic stimulation L left R right tDCS transcranial direct current stimulation medicine.disease Brain Waves Brain stimulation Physical therapy business Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 22, Iss, Pp-(2019) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Abnormal cortical oscillations are markers of Parkinson's Disease (PD). Transcranial alternating current stimulation (tACS) can modulate brain oscillations and possibly impact on behaviour. Mapping of cortical activity (prevalent oscillatory frequency and topographic scalp distribution) may provide a personalized neurotherapeutic target and guide non-invasive brain stimulation. This is a cross-over, double blinded, randomized trial. Electroencephalogram (EEG) from participants with PD referred to Specialist Clinic, University Hospital, were recorded. TACS frequency and electrode position were individually defined based on statistical comparison of EEG power spectra maps with normative data from our laboratory. Stimulation frequency was set according to the EEG band displaying higher power spectra (with beta excess on EEG map, tACS was set at 4 Hz; with theta excess, tACS was set at 30 Hz). Participants were randomized to tACS or random noise stimulation (RNS), 5 days/week for 2-weeks followed by ad hoc physical therapy. EEG, motor (Unified Parkinson's Disease Rating Scale-motor: UPDRS III), neuropsychological (frontal, executive and memory tests) performance and mood were measured before (T0), after (T1) and 4-weeks after treatment (T2). A linear model with random effects and Wilcoxon test were used to detect differences. Main results include a reduction of beta rhythm in theta-tACS vs. RNS group at T1 over right sensorimotor area (p = .014) and left parietal area (p = .010) and at T2 over right sensorimotor area (p = .004) and left frontal area (p = .039). Bradykinesia items improved at T1 (p = .002) and T2 (p = .047) compared to T0 in the tACS group. In the tACS group the Montréal Cognitive Assessment (MoCA) improved at T2 compared with T1 (p = .049). Individualized tACS in PD improves motor and cognitive performance. These changes are associated with a reduction of excessive fast EEG oscillations. Highlights • Personalized tACS protocols improve motor and cognitive performance in PD. • Among motor items, bradykinesia improved most. • Fast cortical oscillations decreased after tACS. |
| Databáze: | OpenAIRE |
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