PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players
| Autor: | Viviana Izzo, Pasqualina Buono, Dino Sangiorgio, Ausilia Elce, Aurora Daniele, Ersilia Nigro, Olga Scudiero, Maria Ludovica Monaco, Giovanni Villone |
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| Přispěvatelé: | Scudiero, Olga, Nigro, Ersilia, Elce, Ausilia, Izzo, Viviana, Monaco, Maria Ludovica, Sangiorgio, Dino, Buono, Pasqualina, Villone, Giovanni, Daniele, Aurora |
| Rok vydání: | 2017 |
| Předmět: |
PPARγ and ADRB3 genes
Irisin Physical activity Water polo players Adiponectin 0301 basic medicine Irisin medicine.medical_specialty Adipose tissue Adipokine 030209 endocrinology & metabolism Single-nucleotide polymorphism Biology 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Myokine PPARg Genetic predisposition medicine Orthopedics and Sports Medicine Adiponectin Physical activity ADRB3 irisin adiponectin water polo players physical activity PPARγ and ADRB3 gene Adiponectin Irisin Physical activity PPARγ and ADRB3 genes Water polo players 030104 developmental biology Endocrinology Water polo player PPARγ and ADRB3 genes Hormone |
| Zdroj: | Sport Sciences for Health. 13:395-401 |
| ISSN: | 1825-1234 1824-7490 |
| DOI: | 10.1007/s11332-017-0371-8 |
| Popis: | Background: Response to exercise is regulated by environmental factors and genetic predisposition. PPARγ and ADRB3 genes are associated with body composition. Adipose and muscle tissues secrete adipokines and myokines involved in energy expenditure; among the others, adiponectin and Irisin were associated with benefits of physical activity. Aims: Here we investigate two common variants in PPARγ and ADRB3 genes (Pro12Ala, Trp64Arg, respectively) and the expression of Irisin in 22 professional water polo (WP) players versus 40 controls. Methods: Anthropometric and hormonal parameters were assessed; Pro12Ala and Trp64Arg SNPs were analyzed by direct-sequencing; adiponectin and Irisin expression was evaluated through western blotting. Results: Irisin levels were similar between WP athletes and controls. The Pro12Ala polymorphism was present in two WP players and two controls while the Trp64Arg polymorphism only in one WP player; both polymorphisms were not related to biochemical parameters, as well as to Irisin and adiponectin expression. Conclusions: Our study suggests that the influence of two PPARγ and ADRB3 common polymorphisms on Adiponectin and Irisin expression in WP athletes is limited, if it exists at all. Further studies are needed to clarify if the positive effects mediated by physical training may pass through the regulation of Irisin, adiponectin and genetic background. |
| Databáze: | OpenAIRE |
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